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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
TTK
All Species:
24.85
Human Site:
T46
Identified Species:
45.56
UniProt:
P33981
Number Species:
12
Phosphosite Substitution
Charge Score:
0.33
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P33981
NP_003309.2
857
97072
T46
N
K
I
S
A
D
T
T
D
N
S
G
T
V
N
Chimpanzee
Pan troglodytes
XP_001146752
857
97034
T46
N
K
I
S
A
D
T
T
D
N
S
G
T
V
N
Rhesus Macaque
Macaca mulatta
XP_001111082
778
87619
S37
E
D
L
T
D
E
L
S
L
N
K
I
S
A
D
Dog
Lupus familis
XP_539016
855
96614
T46
N
K
V
S
A
D
S
T
D
N
S
G
T
V
N
Cat
Felis silvestris
Mouse
Mus musculus
P35761
856
96192
D43
S
L
S
K
I
C
A
D
H
T
E
T
V
N
Q
Rat
Rattus norvegicus
NP_001101642
835
94323
D43
N
S
I
K
V
C
V
D
P
T
E
T
V
N
Q
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001512474
935
104827
T46
T
K
I
S
T
D
T
T
D
N
S
G
T
V
N
Chicken
Gallus gallus
XP_419867
879
99691
T49
T
K
I
S
A
D
T
T
D
N
S
G
T
V
N
Frog
Xenopus laevis
NP_001082090
882
99060
T47
S
K
S
S
A
D
T
T
E
H
S
G
I
F
T
Zebra Danio
Brachydanio rerio
Q8AYG3
982
109993
D45
A
I
S
S
N
S
P
D
T
C
R
T
F
L
S
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
XP_002301009
818
91361
V46
P
P
D
F
L
R
H
V
Q
A
A
F
K
R
H
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
NP_565160
777
86358
S35
T
S
S
S
S
S
S
S
S
S
S
P
E
L
L
Baker's Yeast
Sacchar. cerevisiae
P54199
764
86809
D23
T
N
T
R
Q
F
S
D
D
E
E
F
T
T
P
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.1
85.7
87.4
N.A.
74.3
76.9
N.A.
64.2
61
52.8
41.4
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
100
99.6
87.7
92.6
N.A.
84.8
85.6
N.A.
73.6
74.5
68.4
57
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
100
100
6.6
86.6
N.A.
0
13.3
N.A.
86.6
93.3
53.3
6.6
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
100
100
46.6
100
N.A.
6.6
13.3
N.A.
86.6
93.3
73.3
20
N.A.
N.A.
N.A.
N.A.
N.A.
Percent
Protein Identity:
23.1
N.A.
N.A.
22.9
22.7
N.A.
Protein Similarity:
40.2
N.A.
N.A.
42.3
44.5
N.A.
P-Site Identity:
0
N.A.
N.A.
13.3
13.3
N.A.
P-Site Similarity:
13.3
N.A.
N.A.
46.6
20
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
8
0
0
0
39
0
8
0
0
8
8
0
0
8
0
% A
% Cys:
0
0
0
0
0
16
0
0
0
8
0
0
0
0
0
% C
% Asp:
0
8
8
0
8
47
0
31
47
0
0
0
0
0
8
% D
% Glu:
8
0
0
0
0
8
0
0
8
8
24
0
8
0
0
% E
% Phe:
0
0
0
8
0
8
0
0
0
0
0
16
8
8
0
% F
% Gly:
0
0
0
0
0
0
0
0
0
0
0
47
0
0
0
% G
% His:
0
0
0
0
0
0
8
0
8
8
0
0
0
0
8
% H
% Ile:
0
8
39
0
8
0
0
0
0
0
0
8
8
0
0
% I
% Lys:
0
47
0
16
0
0
0
0
0
0
8
0
8
0
0
% K
% Leu:
0
8
8
0
8
0
8
0
8
0
0
0
0
16
8
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
31
8
0
0
8
0
0
0
0
47
0
0
0
16
39
% N
% Pro:
8
8
0
0
0
0
8
0
8
0
0
8
0
0
8
% P
% Gln:
0
0
0
0
8
0
0
0
8
0
0
0
0
0
16
% Q
% Arg:
0
0
0
8
0
8
0
0
0
0
8
0
0
8
0
% R
% Ser:
16
16
31
62
8
16
24
16
8
8
54
0
8
0
8
% S
% Thr:
31
0
8
8
8
0
39
47
8
16
0
24
47
8
8
% T
% Val:
0
0
8
0
8
0
8
8
0
0
0
0
16
39
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _